Not as an accelerator,only the 2.2 version works with audiomedia cards.But it should be possible to play the audio through it, if you use the sound manager playback setting and set the sound control panel to the audiomedia card.To set up sound manager see here: https://happymacs.wordpress.com/tag/audiomedia-ii/ (not mine).The turbosynth manual is here http://theviirus.files.wordpress.com/2013/08/turbosynth_manual.pdf but i will upload it here too (not mine either).