QTR-Quadtone RIP

Roy wrote: 

"Whenever you use any ICC profile for printing, its only appropriate 
for printing with the exact same settings that were used to create the 
profile. So if you make a profile with QTR its only good for printing 
with QTR."

That is the part I have had trouble understanding, since QTR does not 
allow one to apply the profile.

I guess, if you use one of the RGB partition methods (Roark-type) or 
ABW, one could indeed use the profile for printing with the Epson 
driver. Am I missing something?

Shilesh