QTR-Quadtone RIP

Have you compared performance/reliability/grief of CIS setups from Ink
Supply/MIS vs Cone/Piezo ? 

Not talking about the ink, just the CIS.

I've been negative on the CIS idea for years due to all the bad
reports, but my remaining 2200 has served well and I figure it's OK to
take this risk in its old age (will eventually replace with 2400-II or
whatever). 

Which is best? I'd rather pay a premium than struggle (my MIS carts
were junk, but CIS might be another ball game). Is another CIS else
better?