QTR-Quadtone RIP

Hello. I have a couple questions about QTR. I have never used it. I have an Epson 1400 and would like to try printing BO..

When using this software to print, do I have to make any adjustments to the Epson driver first?

Does the image to be printed with QTR have to be fully prepared first (cropped, sharpened)?

Is this a stand alone application?

Thank you very much. Any tips would also be kindly appreciated.

Francis