Digital BW, The Print

I'm attempting to refine the curves for MIS VM for my 1270.
Each time I open the file it first informs...
Embedded is Grey Gamma 2.2
Working is Grey Gamma 1.8

I'm on a PC and used SpyderCal to calibrate the monitor and I'm 
pleased with the visual relation to prints, so I would just as well 
leave those settings alone...though I don't know what I've therefore 
adjusted and become outside the norm.

Question A - Is there a preference or dominance being used by MIS VM 
users regarding Gamma?

Question B - What are the implications of converting?

Thanks,
Cleavis - trying to understand & not particularly fond of the fact 
that there are soooo many linkages that affect/effect one another in 
a computer.